CZ.1.07/2.3./20.0303

Přednáška Genomics of Introgression across a Species Barrier: Half a Million SNPs across the European House Mouse Hybrid Zone

21.6.2013 se na Ústavu biologie obratlovců, detašovaném pracovišti ve Studenci konala přednáška na téma Genomics of Introgression across a Species Barrier: Half a Million SNPs across the European House Mouse Hybrid Zone. Přednášel Stuart J.E.Baird.

Autoři: Stuart J.E. Baird, Miloš Macholán, Pavel Munclinger, Jaroslav Piálek

Abstract: Understanding speciation as a birth-death process requires study not only of the maintenance of species barriers, but also of those forces acting to break them down. We use the European House Mouse hybrid zone as a natural experiment to examine such forces. When SNP marker data is dense on the recombination map it cannot be treated as a series of independent loci but can, instead and more naturally, be analysed in terms of Fisher’s representation of the outcome of admixture and recombination: the ancestral source of blocks of DNA along the genome and the position of junctions (arising from recombination) where that source state changes. Cascades in the size of blocks allow ancestral polymorphism to be distinguished from introgression polymorphism. Frequency spectra of introgressed block sizes allow inference of the time since secondary contact. Geographic outlier analysis of blocks allow regions of the genome associated with the introgression of a Y chromosome across the species barrier to be identified. These insights increase our understanding not only of the mouse species barrier, but also how it can decay in its natural setting.